Herbal origins provision for non-enzymatic Glycation, (NEGs) inhibition

Mohammad Nadeem Khan, Ragini Gothalwal

SOS in Biotechnology, Bastar University, Jagdalpur (Chhattisgarh) 494001, India

Department of Biotechnology and Bioinformatics Centre, Barkatullah University, Bhopal (M.P.) 462026, India

Accepted 24 November 2017

Citation: Khan MN, Gothalwal R (2018). Herbal origins provision for non-enzymatic Glycation, (NEGs) inhibition. Frontiers in Medicinal Chemistry and Drug Discovery, 2(1): 010-015.

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Copyright: © 2018 Khan and Gothalwal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Abstract

The aldehyde or ketone groups of reducing sugars react non-enzymatically with the free amino groups of proteins, lipids and nucleic acids leading to the formation of advanced glycation end products (AGEs).  These AGEs inhibitory   API (active pharmaceutical ingredients   carries a great deal of   AGEs   in reducing the risk to related diseases and puts the clinician in a predicament to find concise and reliable information for adequate class of drug and its anti-glycating activity.Thus far, some potentially is interesting inhibitors   forms herbal origins with all possible mechanisms of inhibition of   AGEs.  The study have focused on   herbal origins inhibitors API followwhich class ofinhibitor.A various in-vitro and in-vivomodel studythe evaluation AGEs inhibitory drugs.Present discussion concluded that the investigated Armed with herbal phytochemicals specific inhibitors, glycobiologists will be able to explore the biological function of the individual phytochemicals in NEGs and AGEs.

Key words: NEGs, AGEs, hyperglycemia, glycation, Amadori products, Herbal drugs