Herbal origins provision for non-enzymatic Glycation, (NEGs) inhibition
Mohammad Nadeem Khan, Ragini Gothalwal
SOS in Biotechnology, Bastar University, Jagdalpur (Chhattisgarh) 494001, India
Department of Biotechnology and Bioinformatics Centre, Barkatullah University, Bhopal (M.P.) 462026, India
Accepted 24 November 2017
Citation: Khan MN, Gothalwal R (2018). Herbal origins provision for non-enzymatic Glycation, (NEGs) inhibition. Frontiers in Medicinal Chemistry and Drug Discovery, 2(1): 010-015.
Copyright: © 2018 Khan and Gothalwal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.
The aldehyde or ketone groups of reducing sugars react non-enzymatically with the free amino groups of proteins, lipids and nucleic acids leading to the formation of advanced glycation end products (AGEs). These AGEs inhibitory API (active pharmaceutical ingredients carries a great deal of AGEs in reducing the risk to related diseases and puts the clinician in a predicament to find concise and reliable information for adequate class of drug and its anti-glycating activity.Thus far, some potentially is interesting inhibitors forms herbal origins with all possible mechanisms of inhibition of AGEs. The study have focused on herbal origins inhibitors API followwhich class ofinhibitor.A various in-vitro and in-vivomodel studythe evaluation AGEs inhibitory drugs.Present discussion concluded that the investigated Armed with herbal phytochemicals specific inhibitors, glycobiologists will be able to explore the biological function of the individual phytochemicals in NEGs and AGEs.
Key words: NEGs, AGEs, hyperglycemia, glycation, Amadori products, Herbal drugs