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Ahmed Bendary
Osama Sanad
Eman Al-Keshk
Ahmed Ramzy
Mohammed A. Tabl
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Ahmed Bendary
Osama Sanad
Eman Al-Keshk
Ahmed Ramzy
Mohammed A. Tabl
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International Journal of Cardiology and Cardiovascular Research

Characteristics of coronary artery ectasia and its association with carotid intima-media thickness and high sensitivity C-reactive protein

Osama Sanad, Eman Al-Keshk, Ahmed Ramzy, Mohammed A.Tabl, Ahmed Bendary

Cardiology department, Benha university hospital, Benha faculty of medicine, Egypt.

Accepted 17 June, 2016.

Citation: Sanad O, Al-Keshk E, Ramzy A, Tabl MA, Bendary A (2016). Characteristics of coronary artery ectasia and its association with carotid intima-media thickness and high sensitivity C-reactive protein. International Journal of Cardiology and Cardiovascular Research, 3(1): 024-030.

 

Copyright: © 2016 Bendary et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Abstract

This study was conducted to uncover the relation between coronary artery ectasia (CAE) and markers of atherosclerosis. A total of 1611 coronary angiograms were prospectively examined to find out patients with CAE. Those patients were divided into 2 groups: Mixed CAE with stenotic coronary artery disease (CAD) “group 1” and pure CAE “group 2”. Two control groups of age-adjusted subjects were selected consecutively in a 1:1 fashion; one with normal coronaries “group 3” (Pure CAE: normal coronaries) and the other with obstructive CAD only “group 4” (Mixed CAE: obstructive CAD). All recruited subjects underwent carotid intima-media thickness (IMT) and high sensitivity C-reactive protein (hs-CRP) level measurements. Out of examined angiograms, 35 subjects showed mixed CAE “group 1” and 26 showed pure CAE “group 2”. Age and gender-adjusted logistic regression analysis model revealed that significant independent predictors for CAE were: hypertension, smoking, absence of DM and hs-CRP level > 3 mg/L. Mean carotid IMT was significantly higher in group 2 than group 3 and in group 4 than group 1 (1±0.1 versus 0.4±0.2 mm and 1.4±0.4 versus 1±0.2 mm respectively, P < 0.001 for both). Mean hs-CRP level was significantly higher in group 1 than group 4 and in group 2 than group 3 (7±2 versus 3±0.8 mg/L and 6±2 versus 1±0.6 mg/L respectively, P < 0.001 for both). We concluded that atherosclerosis may not be the only plausible explanation for CAE.

Keywords: Coronary artery ectasia; Carotid intima-media thickness; high sensitivity C-reactive protein; Atherosclerosis.

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