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*Adumanya OCU
Uwakwe AA
Essien EB
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Uwakwe AA
Essien EB
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International Journal of Ethnopharmacology

Antiplasmodial activity of methanol leaf extract of Salacia senegalensis Lam (Dc) in Albino Mice infected with chloroquine-sensitive Plasmodium berghei berghei (NK65)

*Adumanya OCU, Uwakwe AA and Essien EB

Accepted 21 September, 2014.

Citation: Adumanya OCU, Uwakwe AA, Essien EB (2014). Antiplasmodial activity of methanol leaf extract of Salacia senegalensis Lam (Dc) in Albino Mice infected with chloroquine-sensitive Plasmodium berghei berghei (NK65). International Journal of Ethnopharmacology, 1(1): 002-006.

Copyright: © 2014 Adumanya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Abstract

The antiplasmodial effect of methanol leaf extract of Salacia senegalensis were evaluated in albino mice infected with chloroquine-sensitive Plasmodium berghei berghei (NK65) in order to justify or otherwise  its use as antimalarial remedy in Nigeria folk medicine. Activities investigated were suppressive effect against early infection, curative effect against established infection and prophylactic effect against residual infection. Results showed a dose dependent blood schizontocidal activity at all the phases of malarial infection studied. The in vivo antiplasmodial effect of the extract (1000, 1200 and 1400 mg/kg body weight) against P. berghei showed significant (p < 0.05) dose-dependent activity for suppressive, curative and prophylactic test. When the extract dose increased from 1000 to 1400 mg/kg/day, chemosuppressive activity of the extract increased from 66.47 % to 80.33 %. There was also an increase from 66.57 % to 75.41 % and from 64.90 % to 82.72 % for the repository and curative activities respectively. The schizontocidal activities were comparable to that of chloroquine -which had percentage suppression of parasitaemia as 87.03 %, 85.12 %, and 91.68 % for suppressive, prophylactic and curative activities respectively). It was thus concluded that the herbal extract possesses significant antimalarial potency which could be exploited in the formulation of antimalarial drugs. 

Keywords: Antiplasmodial, Salacia senegalensis, Plasmodium berghei, chemosuppression, schizontocidal.

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