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Younes Abrouki
Abdelkader Anouzla
Hayat Loukili
Abdelkarim Abrouki
Rabiaa Lotfi
Ahmed Rayadh
My Abdellah Bahlaoui
Driss Zakarya
Mohamed Zahouily
Saïd Sebti
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Younes Abrouki
Abdelkader Anouzla
Hayat Loukili
Abdelkarim Abrouki
Rabiaa Lotfi
Ahmed Rayadh
My Abdellah Bahlaoui
Driss Zakarya
Mohamed Zahouily
Saïd Sebti
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International Research Journal of Chemistry and Chemical Sciences

A green and efficient friendly process for synthesis of drug against dormant version of the Mycobacterium tuberculosis H37Ra

Younes Abrouki*, Abdelkader Anouzla, Hayat Loukili, Abdelkarim Abrouki, Rabiaa Lotfi, Ahmed Rayadh, My Abdellah Bahlaoui, Driss Zakarya, Mohamed Zahouily, Saïd Sebti

Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia, Morocco

Department of Chemistry, Faculty of Science Ben M'Sik, University Hassan II, Casablanca, Morocco.

Accepted 15 July, 2017

Citation: Abrouki Y, Anouzla A, Loukili H, Abrouki A, Lotfi R, Rayadh A, Bahlaoui MA, Zakarya D, Zahouily M, Sebti S (2017). A green and efficient friendly process for synthesis of drug against dormant version of the Mycobacterium tuberculosis H37Ra. International Research Journal of Chemistry and Chemical Sciences, 4(1): 049-054.

 

Copyright: © 2017 Abrouki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Abstract

The objective of this study is the synthesis of (2E,6E)-2,6-bis(4-nitrobenzylidene)cyclohexanone by the cross-aldol condensation between 4-nitrobenzaldehyde and cyclopentanone catalyzed by modified fluorapatite in aqueous media and the reaction conditions were optimized by the response surface methodology. This process is an important protocol for the synthesis of drug against dormant version of the Mycobacterium tuberculosis H37Ra. The work-up procedure is simplified by simple filtration with high yield and by-products of usual undesirable reaction are not observed.

Keywords: (2E,6E)-2,6-bis(4-nitrobenzylidene) cyclohexanone, Anti-Tuberculosis Drug, Mycobacterium tuberculosis H37Ra, Modified Fluorapatite, Cross-aldol condensation

 

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