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Tarik Sqalli
Mohamed Arrayhani
El youbi Randa*
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Tarik Sqalli
Mohamed Arrayhani
El youbi Randa*
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Journal of Diseases and Disorders

Prognostic factors in small vessel vasculitis with renal impairment: Monocentric study

El youbi R*, Mohamed A, and Tarik S

Accepted 13 February, 2014.

Citation: El youbi et al. (2014). Prognostic factors in small vessel vasculitis with renal impairment: monocentric study. J. Dis. Disorders. 1(1): 002-004.

Copyright: © 2014 El youbi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Abstract

The kidney is one of preferred target for many forms of small vessels vasculitis. The objective of our work is to highlight risk factors of death and renal survival in small vessel vasculitis with renal impairment. A retrospective study conducted in the Department of Nephrology at the University Hospital Hassan II of Fez between April 2010 and April 2013. Of the 30 cases included, twenty-one patients had vasculitis associated to Anti-cytoplasmic antibodies neutrophil. The average age was 46.5 ± 16.17 (23-76 years old), with female predominance (sex ratio 0.6 ). The main reasons for hospitalization were severe kidney failure in 20% of cases, and hemoptysis in 53.3%.  All patients have received corticosteroids and cyclophosphamide. After one year, the evolution was marked by complete remission in 26.6%, relapse in 13.3%, and chronic renal failure in 30%. Seven cases of deaths were noted. In univariate analysis, hypertension and the presence of sclerotic glomeruli were predictive factors associated with death. Renal prognosis was significantly correlated to early dialysis.  We have identified a number of risk factor associated to unfavorable evolution which are: hypertension, presence of sclerotic glomeruli , and  early dialysis.

 Keywords: Dialysis, hypertension, sclerotic glomeral, kidney, prognosis, vasculitis.