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Hitesh Verma*
Surinder K Singhal
Dev Raj
Nitin Gupta
Arjun Dass
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Hitesh Verma*
Surinder K Singhal
Dev Raj
Nitin Gupta
Arjun Dass
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Journal of Dermatology, Venereology and Leprology

Synchronous malignancy in xeroderma pigmentosum and issues in management

Hitesh Verma*, Arjun Dass, Surinder K Singhal, Nitin Gupta, Dev Raj

Accepted 15 June, 2014.

Citation: Verma H, Dass A, Singhal SK, Gupta N, Raj D (2014). Synchronous malignancy in xeroderma pigmentosum and issues in management. Journal of Dermatology, Venereology and Leprology, 1(1): 002-004.

Copyright: © 2014 Verma et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.


Xeroderma pigmentosum (XP) is a genetic disorder of autosomal recessive transmission, characterized by photosensitivity, pigmentary changes, premature skin aging and malignant tumour development due to cellular hypersensitivity to ultraviolet radiation. This hypersensitivity results from a defect in DNA repair. The XP is known to have multiple cutaneous malignancies in sun exposed areas, which are usually treated by surgery. The surgical excision of the tumor should be complete and oncologically safe, as the use of postoperative radiotherapy is controversial. This case report describes synchronous basal cell carcinoma and squamous cell carcinoma occurring at the head and neck region of a young individual with xeroderma pigmentosum. Here, attempts have been made to highlight the difficulties encountered in such individuals while managing lesions located in close proximity to each other.

Key words: Xeroderma pigmantosum, synchronous malignancies, squamous cell carcinoma, basal cell carcinoma, hypersensitivity