JDVL Navigation
About
Publication Ethics
Call For Paper
Guide to Authors
Editorial Board
Submit Manuscript
Articles
Viewing Options
[View Abstract]
[View Full Text PDF]
[View Full Text PDF]
Authors Articles on Google Scholar
Hitesh Verma*
Surinder K Singhal
Dev Raj
Nitin Gupta
Arjun Dass
Authors Articles on Pubmed
Hitesh Verma*
Surinder K Singhal
Dev Raj
Nitin Gupta
Arjun Dass
Preferences
Email this Article to a friend
Print this Article
Statistics
Viewed: 706
Forwarded: 0
Printed: 121
Downloaded: 904
Browse Journals By Category
Agriculture and Food Sciences
Biological Sciences
Education and Arts
Engineering
Environmental Sciences
Medical Sciences
Pharmaceutical Sciences
Physical and Natural Sciences
Social Sciences

Newsletters Subscription

Journal of Dermatology, Venereology and Leprology

Synchronous malignancy in xeroderma pigmentosum and issues in management

Hitesh Verma*, Arjun Dass, Surinder K Singhal, Nitin Gupta, Dev Raj

Accepted 15 June, 2014.

Citation: Verma H, Dass A, Singhal SK, Gupta N, Raj D (2014). Synchronous malignancy in xeroderma pigmentosum and issues in management. Journal of Dermatology, Venereology and Leprology, 1(1): 002-004.

Copyright: © 2014 Verma et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.

Abstract

Xeroderma pigmentosum (XP) is a genetic disorder of autosomal recessive transmission, characterized by photosensitivity, pigmentary changes, premature skin aging and malignant tumour development due to cellular hypersensitivity to ultraviolet radiation. This hypersensitivity results from a defect in DNA repair. The XP is known to have multiple cutaneous malignancies in sun exposed areas, which are usually treated by surgery. The surgical excision of the tumor should be complete and oncologically safe, as the use of postoperative radiotherapy is controversial. This case report describes synchronous basal cell carcinoma and squamous cell carcinoma occurring at the head and neck region of a young individual with xeroderma pigmentosum. Here, attempts have been made to highlight the difficulties encountered in such individuals while managing lesions located in close proximity to each other.

Key words: Xeroderma pigmantosum, synchronous malignancies, squamous cell carcinoma, basal cell carcinoma, hypersensitivity